Research & Development

Canker Cover®
is an innovative and effective treatment designed to treat oral sores (aphthas) and prevent their reoccurrence. Canker Cover® immediately soothes pain and heals the oral sore (aphtha) within 24 to 48 hours. 

A new study proves that Canker Cover heals most canker sores in just one day compared to 120 hours for a representative benzocaine based product. 

- Immediate Pain Relief
- Protects the sore - stops pain from food, drink and irritants
- Sticks to any canker sore and becomes a clear gel patch
- Stays on comfortably for 8 to 12 hours, then dissolves
- Won't come off while eating
- Freshens breath
- A single patch fully treats most canker sores
- Contents treat 4-6 canker sores

Canker Cover is a tablet-like patch made from edible ingredients. It sticks to any canker sore within seconds, and then forms a clear, gel patch that lasts 8 - 12 hours. The patch protects the sore from irritants - food, drink, braces, etc., and releases nutrients that support healing. A single patch will treat most canker sores. 

Canker Cover Works in Three Ways:

1. The natural ingredients in Canker Cover speed healing. Most canker sores are eliminated with a single patch.

2. Canker Cover "seals" and isolates the canker sore from contact with the tongue, teeth, and food. No other canker sore treatment products protect so thoroughly for eight hours.

3. Canker Cover provides immediate and long lasting pain relief by steadily releasing pain-numbing menthol, beta-carotene and other natural ingredients onto the sore.

Directions: (adults & children 5 years of age and older)
Place the Canker Cover patch on a clean, dry finger with the white side up. The sore should be dry (pat with tissue, if possible). Place the white side of the tablet on the sore and hold in place for 20 seconds. Some discomfort may occur during the first few minutes for a small number of users, but will quickly subside followed by hours of soothing relief. Within 30 minutes the tablet becomes a clear, gel-like patch that will cover the sore for 8-12 hours before dissolving. Do not remove patch before it dissolves. In case of discomfort, the patch may be removed by gently peeling the tablet from the sides and washing with water. Avoid the use of any instrument to remove the patch. If needed, apply a second patch 24 hours after the first application. In most cases, just one patch is needed. 

The study, conducted by the Hebrew University, Jerusalem, was published in The January, 2008 issue of Drugs in R&D, a peer reviewed journal.

The study evaluated the efficacy and tolerability of two topical medications for the treatment of canker sores (aphthous stomatitis), Canker Cover, an oral patch and Kanka, a benzocaine based oral solution. Benzocaine and similar acting pain-relieving ingredients are found in the majority of over-the-counter canker sore treatments.

48 patients were enrolled to the study. 7 patients left due to personal reasons. 23 patients were treated with the oral patch containing citrus oil, a carnelite mineral blend and menthol and 20 were treated with the oral solution containing benzocaine and benzoine t.i.d. The oral patch was found to be significantly more effective in terms of healing time andpain relief, and had fewer side effects.

Median healing time was 23.8 hours for the oral patch vs. 120 hours for the oral solution; pain levels were significantly lower among oral patch users after 12 and 24 hours; and more patients reported local side effects when using the oral solution than when using the oral patch users. 86.9% of the oral patch groups would use the treatment again, compared to 50% of the oral solution group.

There was no significant difference between the two treatments regarding overall ease of use of the treatment or patient's ability to speak one hour after application of the drug. However, 35% of the oral solution patients had difficulty swallowing saliva one hour after application, compared to 4% of the oral patch patients.

Regarding side effects, 100% of the patients using the oral solution reported having one or more side effects effect (numbing, tingling, local pain, bad taste) one hour after the application of the medication and throughout the healing process. Those adverse effects (with the exception of bad taste, which was reported by 4 oral solution patients but was not reported at all among oral patch patients) were reported only among 43.5% of the patients using the oral patch, and only one hour after treatment application. After one hour, oral patch users had no measurable side effects

Dr. Shemer concludes: "The oral patch, Canker Cover, was found to be significantly more effective and tolerable than the oral solution (Kanka) in the treatment of aphthous stomatitis."

This new study confirms similar conclusions from a previous study conducted on 248 patients and published in the Journal of Pharmaceutical Sciences (93:2927-2935). In that study, the efficacy of the Canker Cover patch was compared to a similar oral patch without active ingredients. The time of healing was approximately 1 day for Canker Cover, 5 days for the plain patch and 10 days for untreated patients. The average time for pain disappearance was reduced from 134 hours for the untreated patients, to 48 hours for the group treated with plain patches, and to 5 hours in patients treated with Canker Cover. Furthermore, Canker Cover adhered to the sore sore for 8 - 12 hours providing full protection from food and drink irritation.

"The benefit to canker sore sufferers is quite clear", said Dr.Shemer. "The oral patch heals canker sores in a day, stops pain and protects the sore from food and drink irritants for 8 - 12 hours at a time."

Canker CoverTM is a tablet-like patch made from edible ingredients. It adheres to the canker sore within seconds and forms a clear, gel-like protective ‘seal' that lasts 8 to 12 hours. The patch completely stops the pain, protects the sore from tongue, teeth, food, drink and other irritants, and won't come off while eating. While on, the patch releases menthol, sea salt, citrus oil and other nutrients which prevent pain and speed the healing process. For most users, a single patch is all that is needed. As an added benefit, the patch keeps breath fresh. For more details, visit

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